Abstract
This study is a retrospective review of Cochrane CENTRAL database, MEDLINE, and Embase through June 15, 2018. Analysis of 22 studies involving 80,428 patients with abdominal aortic aneurysms (AAAs) revealed that statin use is associated with a mean AAA growth rate reduction of 0.82 mm/y (P = .001), lower rupture risk (P < .0001), and lower 30-day mortality after elective AAA repair (P = .005). The crude rupture rate was 34% for statin patients and 47% for control patients. The crude 30-day mortality rate was 1.8% for the statin group and 2.6% for the control group. The largest effect was in patients who underwent open AAA repair as opposed to endovascular aneurysm repair. Statin use may be associated with reduction in AAA growth, rupture, and perioperative mortality after elective AAA repair.
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