Abstract
Statins modulate the expression profile of ATP-binding cassette transporters in human neuroblastoma cells
Highlights
The development of chemoresistance still is a major problem in cancer therapy
We demonstrated that simvastatin coadministrated with the anthracycline doxorubicin led to increased apoptosis in neuroblastoma cells, and that these effects were comparable with the potential of verapamil, a first generation inhibitor of ABCB1 [1]
Here we show that simvastatin is able to modulate ABCB1 expression
Summary
The development of chemoresistance still is a major problem in cancer therapy. Impact of chemotherapy is based on the upregulation of ATP-binding cassette (ABC) transporters, which correlates with bad prognosis and less chemotherapeutic success. We could show that the HMG-CoA reductase inhibitor simvastatin is able to inhibit the most prominent ABC transporter ABCB1. We demonstrated that simvastatin coadministrated with the anthracycline doxorubicin led to increased apoptosis in neuroblastoma cells, and that these effects were comparable with the potential of verapamil, a first generation inhibitor of ABCB1 [1]
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