"STATINS KALEIDOSCOPE". MYOPATHY FROM STATINS

Abstract

Statins are medications that inhibit the 3-hydroxy-3-methylglutaryl-CoA reductase enzyme, thus inhibiting cholesterol biosynthesis. Statins reduce cardiovascular risk and morbidity in patients with coronaropathia, however, without forgetting their side effect in muscle toxicity. Clinically, patients with myopathy caused by statins are divided into four main groups: those with rhabdomyolysis, myalgia / hyper CPK, toxic myopathy limited by statins and myositis (necrotizing myopathy mediated by immune complexes with anti-HMGCR antibodies, IMNM).