Abstract
Aim: Review of the present data from investigations on the role of statins in the treatment of PCOS. Materials and methods: Systematic approach of the available scientific literature on the problem. Results: Polycystic ovary syndrome (PCOS) is common endocrine disorder in women in reproductive age. It is associated with menstrual disorder and disturbance of reproductive and metabolic functions in severe form.Often the syndrome is connected with insulin resistance,systemic inflammation and oxidative stress which lead to endothelial dysfunction and dyslipidemia. Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase with intrinsic antioxidant properties. By blocking an early step of the mevalonate pathway, statins inhibit proliferation of several cell types, improve the lipid and hormone profile of women with PCOS. This article reviews the present data from investigations with statins and their role in PCOS. Conclusions: The recent investigations suggest that statins have potential in the treatment of PCOS.
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