Abstract
Statins offer important benefits for the large populations of individuals at high risk for cardiovascular and cerebrovascular events in both primary and secondary preventions [1]. Due to the positive clinical impact, the concern of statins withdrawal on putative rebound vascular events has been suggested and evaluated both in terms of biological mechanisms or clinical settings as extensively reviewed [2–3]. Furthermore, although from retrospective analysis, several observations have confirmed an increased events rate especially when statins were withdrawn during acute phase of acute vascular stress like coronary syndromes [4–5], major vascular surgery [6–7] and ischemic stroke [8], also in a randomized study [9].
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