Abstract
Aim: to evaluate response to carvedilol given to heart failure patients on chronic treatment with statins. Patients and Methods: 80 males, mean age 55 years (SD = 8.19), with symptomatic heart failure, EF<40%, NYHA class II and III, without prior beta blocker therapy but receiving ACEI and diuretics. Group I – 50 patients on statins (atorvastatin 18.5 = 12.4 mg/daily); group II – 50 patients without statin therapy. Analysis at baseline and at 3 months: NYHA functional class, HRs, echocardiographic parameters ((LVEF, LVDs, LVDd, E/A), exercise capacity using cardiopulmonary exercise testing techniques CPX (t max, METS, VO2peak), heart rate variability by 24h ECG monitoring and plasma levels of BNP, CRP, IL-6 and TNF-alpha.
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