Abstract
BackgroundPsoriasis is associated with hyperlipidemia. Few studies have examined the association among psoriasis, hyperlipidemia, and chronic kidney disease (CKD). It remains a topic of debate whether statin treatment for hyperlipidemia prevents the development of CKD in patients with psoriasis.ObjectiveWe investigated whether there is an association among psoriasis, hyperlipidemia and CKD. If so, we asked whether statin treatment for hyperlipidemia reduces the risk of CKD in patients with psoriasis.MethodsA Taiwan nationwide population-based cohort study between 1997 and 2010 included 2,912 patients with psoriasis and 8,736 matched patients without psoriasis (1:3 propensity score matched according to age, sex, and region); 104,609 patients without psoriasis but with hyperlipidemia and 104,609 matched patients without psoriasis or hyperlipidemia (1:1). The hazard ratios, relative risks, and 95% confidence intervals were calculated using Cox proportional hazards model.ResultsPsoriasis significantly increased the risk of CKD (adjusted hazard ratio 2.48, 95% confidence interval 1.81–3.40), and so did hyperlipidemia (adjusted hazard ratio 2.93, 95% confidence interval 2.79–3.08). Compared to treatment without statins, statin treatment for hyperlipidemia reduced the risk of CKD in patients with psoriasis (adjusted relative risk 0.58, 95% confidence interval 0.55–0.62).ConclusionAs well as hyperlipidemia, psoriasis significantly increased the risk of CKD. Statin treatment for hyperlipidemia reduced the risk of CKD in patients with psoriasis.
Highlights
Psoriasis, traditionally viewed as a chronic inflammatory disorder of the skin, has far-reaching systemic effects.[1]
Psoriasis significantly increased the risk of chronic kidney disease (CKD), and so did hyperlipidemia
Compared to treatment without statins, statin treatment for hyperlipidemia reduced the risk of CKD in patients with psoriasis
Summary
Traditionally viewed as a chronic inflammatory disorder of the skin, has far-reaching systemic effects.[1]. Most studies examining the risk of kidney disease in patients with psoriasis had a small sample size, a cross-sectional design, and varying results.[7]. This study investigated whether statin treatment for hyperlipidemia reduces the risk of CKD in patients with psoriasis. We hypothesized that statin treatment for hyperlipidemia is associated with a reduced risk of CKD in patients with psoriasis. We compared the risks of CKD and ESRD between patients with psoriasis receiving statins for hyperlipidemia and those receiving treatment without statins. Few studies have examined the association among psoriasis, hyperlipidemia, and chronic kidney disease (CKD). It remains a topic of debate whether statin treatment for hyperlipidemia prevents the development of CKD in patients with psoriasis
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