Abstract
We are interested in the report by Li et al. concerning autopsy findings in brains with Alzheimer disease (AD) pathology from patients who had been users of statins compared to brains with AD pathology from nonusers of statins.1 The statin users were defined as those who had received at least three prescriptions (>15 pills per prescription) for simvastatin, lovastatin, pravastatin, or atorvastatin during the period of the study. They report that statin users exhibited a lower burden of both neurofibrillary tangles and neuritic plaques compared with nonusers. However, …
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