Statin or PCSK9 Blocking Alleviate Airway Hyperresponsiveness and Lung Fibrosis In High Fat Diet Induced Obesity Mice

Abstract

Obesity induces airway hyperresponsiveness (AHR) and lung fibrosis, and these features may make asthma patients with obesity respond poorly to typical asthma medications. Statin and blocking proprotein convertase subtilisin/kexin type 9 (PCSK9) decrease serum cholesterol levels, but they also have anti-inflammatory effects. This study examined whether administration of statin or anti-PCSK9 monoclonal antibody alleviated obesity induced lung pathologies.