Abstract
Statins can substantially reduce the risk for cardiovascular events but can also occasionally cause myopathy. High doses of statins increase the risk for myopathy, as does concomitant use of certain drugs, including amiodarone. The Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH), a randomized comparison of 80-mg and 20-mg daily doses of simvastatin, provided an opportunity to investigate whether specific genetic variants are …
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