Statin Drug Therapy May Increase COVID-19 Infection

Sanjaya Kumar Shrestha

doi:10.3126/nmj.v3i1.28256

Abstract

Enveloped viruses like Coronavirus acquire their envelope from the host cell membrane which is a bilayer of phospholipid interspersed with cholesterol molecules and proteins. Viruses enter their host cell by coming in contact with their specific receptors. Experiments have shown that when cell membranes are depleted of cholesterol in vitro by Methyl beta cyclodextrin (MβCD) these Coronaviruses are not able to enter the host cell membrane by the process of receptor mediated endocytosis. Statin inhibits HMG Co-A reductase, a key enzyme in the Mevalonate pathway resulting into either very low or no production of endogenous cholesterol by the human cells. This results into upregulation of LDL-R in the cell membrane which may lead to more cholesterol getting incorporated into the cell membrane through LDL-C from the plasma creating greater number of lipid rafts suitable for entry of enveloped viruses by receptor-mediated endocytosis.

Highlights

Enveloped viruses like the Coronavirus acquire their envelope from the host cell membrane which is a bilayer of phospholipid interspersed with cholesterol molecules and proteins
Receptor-mediated endocytosis of enveloped viruses requires a fusion of the envelope with the host cell membrane, and studies have shown that this process occurs in areas of lipid rafts.[1,2,3]
The mechanism of the Mevalonate pathway exists in almost all the cells of our body because cholesterol is vital for the stability and integrity of the cell membrane as well as intracellular organelles

Summary

Introduction

Enveloped viruses like the Coronavirus acquire their envelope from the host cell membrane which is a bilayer of phospholipid interspersed with cholesterol molecules and proteins. These specific receptors undergo conformational changes and induce fusion of the viral envelope with the host cell membrane leading to receptor-mediated endocytosis of the virus.

Results

Conclusion