Abstract
Myasthenia gravis (MG) can be exacerbated by a variety of medications, which increase weakness by interrupting neuromuscular junction transmission. Statins, which lower lipids by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are not commonly known to worsen MG or have activity against the neuromuscular junction.1 One report suggested that statin therapy produced ocular myasthenia.2 However, based on the case description, it is not clear that this patient had MG.3 We present a patient with well-documented MG who experienced worsening of his condition after taking different statins on four separate occasions. A 55-year-old man with hyperlipidemia and borderline hypertension was evaluated for a 1-year history of intermittent dysarthria. He first noticed dysarthria ∼1 week after the initiation of atorvastatin. At that time, MRI and blood work revealed no evidence of a stroke or …
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