Abstract
Statins, inhibitors of HMG-CoA reductase, have been used for decrease morbidity and mortality not only in cardiovascular disease, but also in important infectious disease like pneumonia and sepsis recently through the anti-inflammatory pleiotropic effects. But it is stil not clear that how statins accom plish these effects. They affect the complex inflammatory cascade mostly regarded as not related to lowering LDL cholesterol, but changing in NO balance, leucocyte–endothelium interactions, and inflammatory cell signaling or gene expression, affecting mononuclear-cell activity, coagulation, fibrino lysis and oxidative stress. Several promising publications demonstrated that statins could get in role in sepsis besides that we expected. In this review, we evaluate the mechanism of action of statins on inflammatory cascade of sepsis and their effects on clinical outcomes.
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