Abstract
ObjectivesTo assess static postural control in eyes-open and eyes-closed conditions in individuals with osteogenesis imperfecta (OI) type I as compared with typically developing (TD) individuals and to explore the relation between postural control and lower limb muscle function. DesignCross-sectional study. SettingOutpatient department of a pediatric orthopedic hospital. ParticipantsA convenience sample (N=38) of individuals with OI type I (n=22; mean age, 13.1y; range, 6–21y) and TD individuals (n=16; mean age, 13.1y; range, 6–20y) was selected. Participants were eligible if they were between 6 and 21 years and if they did not have any fracture or surgery in the lower limb in the 12 months before testing. InterventionsNot applicable. Main Outcomes MeasuresPostural control was assessed through static balance tests and muscle function through mechanographic tests on a force platform. Selected postural parameters were path length, velocity, 90% confidence ellipse area, and the ellipse's length of the mediolateral and anteroposterior axes. Mechanographic parameters were peak force and peak power as measured using the multiple two-legged hopping and the single two-legged jump test, respectively. ResultsIndividuals with OI type I had poorer postural control than did TD individuals as indicated by longer and faster displacements and a larger ellipse area. Muscle function was unrelated to postural control in the OI group. Removing visual information resulted in a larger increase in postural control parameters in the OI group than in the TD group. ConclusionsA proprioceptive deficit could explain poorer postural control in individuals with OI type I.
Highlights
All calculations were performed using IBM SPSS Statistics 20® c. 164 165 Results The majority of the study participants with osteogenesis imperfecta (OI) had a history of femur and/or tibia fracture (Table 1), but these fractures had occurred more than 12 months prior to testing
For the ellipse’s related parameters, there was a main effect of visual conditions indicating that removing visual information resulted in a larger increase in length of the medio-lateral axis ( p = 0.04), whereas a main effect of group showed that the ellipse’s area was larger and both ellipse’s axes longer in the OI group than in the typically developing (TD) group (p = 0.04; p = 0.06; p = 0.03, respectively for the ellipse’s area, the antero-posterior axis and medio-lateral axis). 182 Mechanographic testing showed that lower limbs peak muscle force and relative peak force during multiple two-legged hopping were lower in the OI group than in the TD group (Table 4)
A tendency for lower limbs peak muscle power to be related to velocity (Figure 3 B-D) and path length was observed in both visual conditions. 193 Discussion The present results showed that individuals with OI type I had poorer postural control than typically developing individuals and that this was not associated with muscle weakness
Summary
2. In the absence of a positive family history: presence of at least one fracture and either blue sclerae or dentinogenesis imperfecta and no lower limbs long bones deformities. Sample size was defined by the participants who volunteered to take part in the postural control study. 68 Twenty-two individuals were recruited to participate (mean age [SD]: 13.1 [4.2] years; 14 69 females). In 21 patients, genetic testing had revealed a disease-causing mutation in COL1A1 or COL1A2. Sixteen typically developing individuals (TD) were recruited as controls (mean age [SD]: 12.6 [4.1] years; 10 females). Assent was provided by participants aged between 7 to 17 years. Height and weight were converted to age- and sex-specific z-scores on the basis of reference data published by the Centers for Disease Control and Prevention 12
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