Static and dynamic hyperinflation during severe acute exacerbations of chronic obstructive pulmonary disease

Abstract

Background: Static hyperinflation is known to be increased during moderate exacerbations of COPD (AECOPD), but few data exist in patients with severe COPD or with severe exacerbations of COPD. As far as we are aware, no data have been presented of attempts at measuring dynamic hyperinflation during exacerbations. We were interested in these parameters and their relation to dyspnoea during exacerbations. Methods: In a single center registered trial, we recruited patients admitted to hospital for an AECOPD. The following measurements were performed upon admission, and again after resolution (stable state) at least 42 days later: inspiratory capacity (IC), bodyplethysmography, dynamic hyperinflation by metronome-paced IC measurement, health-related quality of life and dyspnea. Results: Forty COPD patients were included of whom 28 attended follow-up. From exacerbation to stable state, the IC was decreased at admission (2.05±0.11L) and increased again during resolution by 0.28±0.08 L (mean±SEM, p Conclusions: Static hyperinflation is increased during severe AECOPD. We could not demonstrate an increase in metronome paced dynamic hyperinflation during severe AECOPD, possibly due to lack of room for further increase in hyperinflation