Abstract
The size-distribution of DNA labelled by [3H]thymidine during a brief pulse is altered by prior thymine deprivation. The quantity of [3H]thymidine incorporated into long growing chains is constant, irrespective of the current supply of thymine, but the incorporation into short chains is greatly increased. These and other observations have led to a model for DNA replication in which a variable zone of template DNA is available for the initiation of Okazaki pieces. The growth of each piece begins at a slow rate, using a reaction for which thymidine is a good precursor, and finishes at a much faster rate using a reaction for which thymidine is not a preferred precursor.
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