Abstract
Heart and vascular diseases are responsible for tens of millions of deaths annually, underscoring an urgent need to improve the existing clinical practice in order to benefit patients. Advancement of basic science and technology enables understanding of disease etiology and pathogenesis at a deeper level of complexity. This mini-review article provides a summary of recent methods of cell and molecular biology applicable for current cardiovascular research. Widespread application of these approaches in cardiovascular disease research will be a key factor in the prolonged longevity and life expectancy of the general population.
Highlights
Cardiovascular disease (CVD) is the leading cause of mortality and invalidization in the world
Even though the pathophysiology of CVD is generally well studied, while CVD risk factors are modifiable and can be controlled with altered behavior, more basic cardiovascular research is needed to improve current CVD treatment modalities and develop targeted therapies tailored to a patient's requirements
A protein serine protease proprotein convertase subtilisin/kexin type 9 was found to bind low-density lipoprotein (LDL) receptor (LDLR), which induced a conformational change in the LDLR, marking it for lysosomal degradation, which eventually led to a reduced LDL-cholesterol in the blood serum [2, 3]
Summary
Cardiovascular disease (CVD) is the leading cause of mortality and invalidization in the world. This mini-review article provides a summary of recent methods of cell and molecular biology applicable for current cardiovascular research. The last decade has seen a major technological development leading to the emergence of novel methods of cell and molecular biology.
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