Abstract
Cardiomyopathy of obesity in adults is characterized by augmented cardiac output but diminished myocardial performance. This study of healthy adolescent females (mean age 13.7 ± 1.9 years) with a wide range of body fat content was designed to assess evidence of cardiomyopathy in obese youth. Thirteen adolescent females with morbid obesity (body mass index >40 kg m—2) underwent evaluation of resting cardiac size and function as well as cardiac functional reserve during a maximal cycle exercise test. Data were combined with that previously published from this laboratory of nonobese and moderately obese teenage girls and then correlated with body mass index as a marker of obesity. At rest, heart size, stroke volume, and cardiac output were directly related to degree of obesity, whereas a negative correlation was observed between ventricular shortening fraction and body mass index (r = -0.47, P < .01). However, no impairment was observed in cardiac functional reserve with exercise. Maximal cardiac output and ...
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