Abstract
Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. In addition, for several of these diagnoses, we will review medical therapies that can be combined with light-based devices to provide enhanced results.
Highlights
Notable milestones in the treatment of vascular lesions have been achieved over the past century
We will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy
Our aim in this review is to provide an update for the applications of lasers and other light-based devices for cutaneous vascular lesions
Summary
State-of-the-art lasers and light treatments for vascular lesions: from red faces to vascular malformations. We will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. Somatic mutations in the Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) gene have been found in a significant number of SWS and nonsyndromic PWB This mutation has been shown to activate extracellular signal-regulated kinases (ERKs). Approximately 20% of PWB patients are nonresponsive to PDL, in part because good response to PDL may depend on sufficient light penetration, which may be lacking in deep/thick PWBs and in lesions with scarring from previous treatments.[12] Nonresponders may be treated with lasers of different wavelengths, such as the combined 595/1064-nm device, and intense pulsed light (IPL). Experiments with animal models using PDT to target vasculature were performed in
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