Abstract
With recent advances in nanotechnology, various nanomaterials have been used as drug carriers in molecular imaging for the treatment of cancer. The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose. The conventional gold nanoparticles synthetisation methods have limitations with chemical contaminations during the synthesisation process and the use of higher energy. Thus, various innovative approaches in gold nanoparticles synthetisation are under development. Recently, studies have been focused on the development of eco-friendly, non-toxic, cost-effective and simple gold nanoparticle synthesisation. The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle. Therefore, this study aimed to review the eco-friendly gold nanoparticle synthesisation method via the PLAL method and to characterise the gold nanoparticles properties for molecular imaging. This review paper provides new insight to understand the PLAL technique in producing gold nanoparticles and the PLAL parameters that affect gold nanoparticle properties to meet the desired needs in molecular imaging.
Highlights
Recent advances in nanotechnology and nanomaterials offer many possibilities to explore the nanoparticles as a theranostic function in molecular imaging
Gold nanoparticles can be produced through various methods including conventional chemical synthesis, radiation technologies, electrochemical, biosynthesising and pulsed laser ablation in liquid (PLAL) [1,2]
The properties of gold nanoparticles synthesised from the PLAL technique depend on the morphological and geometric characteristics of the particles [56,57]
Summary
Recent advances in nanotechnology and nanomaterials offer many possibilities to explore the nanoparticles as a theranostic function in molecular imaging. Alluhaybi et al emphasised that the PLAL technique is an excellent method in providing high stability, quality and purity of gold nanoparticles without surface contamination [6]. The purity of gold nanoparticles and their larger unique surface (contamination-free) provide a better platform and flexibility for direct conjugating with biocompatible polymers [4,7,10]. This purity resulted in high stability that maintains its shape and chemical properties for up to several years at a room temperature of 26–27 ◦C synthesised gold nanoparticle [11,12].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
