STATE OF PROTEOLYSIS SYSTEM IN THE BASAL GANGLIA OF BRAIN IN CONDITIONS OF PINEAL HYPOFUNCTION

Abstract

Objective - to study a state of proteolysis system in conditions of pineal hypofunction in basal ganglia of rats' brain.Materials and methods. Research was conducted on 48 male rats. Pineal hypofunction was modeled by maintenance of animals during one week in conditions of constant light. Brain structures were taken for study: the caudate nucleus, the nucleus accumbens, the globus pallidus, and the amygdala complex. State of proteolysis system was determined by the activity of proteolytic enzymes responsible for degradation of albumin, casein, collagen and activity of tissue fibrinolysis. Obtained experimental data were analyzed using Students' t-test and processed by methods of variation statistics in "STATISTICA 5.0" software. Significance of pineal hypofunction influence on proteolysis activity was estimated using disperse analysis.Results. Analysis of obtained results has shown that decrease in functional activity of pineal gland results in significant reduction of the proteolysis intensity within basal ganglia of rats' brain.Conclusions. Pineal hypofunction is accompanied by an increase in metabolism intensity in brain basal ganglia which is confirmed by an increase in proteolysis activity in these brain structures. Taking into account an existing idea of pineal gland being an endogenous adaptogen, it may be pointed out that a reduction in its functional activity increases a sensitivity of the organism to influence of pathological factors by changing organism's reaction on stress.