Abstract
Antitumor drug paclitaxel administered in MTD to female rats 1, 3, and 6 months before mating with intact males had a toxic effect on the progeny. We observed increased anteand postnatal mortality, decelerated physical development, low rate of formation of sensorimotor reflexes, impaired learning capacity, and disturbed adaptation behavior. Antenatal mortality considerably increased in the progeny of rats receiving the drug 3 months before mating. The maximum number of pathological changes in viable progeny was found in rats treated with the cytostatic 6 months before mating.
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