STATE OF CELL ENERGY SUPPLY AND ITS AND CORRECTION IN INTENSIVE CARE FOR GASTROINTESTINAL INSUFFICIENCY SYNDROME IN NEONATES

Abstract

In order to improve the intensive care for newborns with gastrointestinal insufficiency syndrome by providing the grounds to use amber acid, we carried out a randomized clinical trial involving 110 newborns with gastrointestinal insufficiency syndrome. The main group included newborns who received infusion with sodium succinate (n = 66) as a part of integrated therapy; the control group included the newborns who were not administered the above mentioned medication (n = 44). At the beginning of the study we observed a tendency towards the formation of lactate acidosis in the examined newborns, while no significant correlation was established between the severity of the gastrointestinal insufficiency syndrome and the indicators of cell energy supply. At the end of the study, the cell energy supply indicators varied in both groups by reducing the level of lactic acid, its ratio regarding pyruvic acid and increase in the activity of succinate dehydrogenase in newborns, who received amber acid in addition to the standard treatment. At the same time we observed a direct significant correlation between the severity of the syndrome of gastrointestinal insufficiency and the level of lactic acid. Thus, the examined newborns with gastrointestinal insufficiency syndrome are found to start developing cell energy disorders that is reflected in the progression and severity of the syndrome. Administration of amber acid medications helps to improve the state of cell energy supply, reducing the manifestations of lactate acidosis and declining the severity and progression of gastrointestinal insufficiency syndrome.