Abstract
Pentameric ligand-gated ion channels (pLGICs) are essential to ultra-fast synaptic transmission. Dysfunction of these channels is associated with a host of debilitating neurological disorders, including congenital myasthenias and Alzheimer’s dementia. Initial studies on pLGICs noted membrane lipid composition to be integral to proper channel function, with certain lipid species causing complete inactivity. Free fatty acid (FFA) lipid species are important to proper neuronal development and FFA levels in synaptic membranes are altered in pathologic states, such as stroke.
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