Abstract
<i>STAT5b</i> in LGL leukemia - a novel therapeutic target?
Highlights
The activation of signal transducer and activator of transcription (STAT) family genes, especially STAT5 and STAT3, has been established in multiple solid tumors and hematological malignancies
Our current findings indicate that activating STAT5b mutations can be found in large granular lymphocytic (LGL) leukemia patients (Rajala et al Blood Apr 17, 2013)
By means of whole exome sequencing we identified a STAT5b mutation Y665F in two STAT3 mutationnegative LGL leukemia patients, and in the following screening of a large patient cohort (n>200) another STAT5b mutation N642H in two additional patients
Summary
The activation of signal transducer and activator of transcription (STAT) family genes, especially STAT5 and STAT3, has been established in multiple solid tumors and hematological malignancies. STAT5b in LGL leukemia – a novel therapeutic target? Our current findings indicate that activating STAT5b mutations can be found in LGL leukemia patients (Rajala et al Blood Apr 17, 2013). LGL leukemia is incurable disease, characterized by chronic expansion of cytotoxic T or NK cells, and it often manifests with other hematological and autoimmune disorders such as rheumatoid arthritis.
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