Abstract
Uterine leiomyomas are benign tumors regulated by gonadal hormones and are composed of an abundance of disorganized extracellular matrix. We have demonstrated that the expression of ECM proteins including collagen and fibronectin are modulated by activated STAT3 and TGFβ3 in leiomyoma cells, indicating an interaction between the two pathways. Our objective in this study was to characterize the changes in STAT3 protein in response to estrogen, progesterone and combination of both. We further examined the interaction between JAK/STAT pathway and downstream regulators of signaling pathways.
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