Abstract
Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.
Highlights
Nanostructured polymers are finding increasing use in pharmaceutical research for the development of drug delivery systems
Evidence shows that the pyrazolo[3,4-d]pyrimidine nucleus can be a valuable scaffold to develop antimicrobial agents [23,24,25] and we evaluated this compound against a series of strains of S. aureus and E. coli
We developed PGA/starch nanocomposites as bio-polymeric matrix carriers for the controlled release of hydrophobic drugs
Summary
Nanostructured polymers are finding increasing use in pharmaceutical research for the development of drug delivery systems. Starch films produced with and without NPs stimulated the growth of intestinal cells For all these reasons, we sought to develop a novel oral drug delivery system consisting of native barley starch blended with PGA NPs in order to obtain a biocompatible nanocomposite to improve the apparent water solubility of drugs. Small molecule KIs can generally be orally administered [12] with remarkable advantages for patient treatment, they are often affected by a poor pharmacokinetic profile This can lead to variations in plasma concentration, insufficient levels of the drug at the site of action, variability in systemic response, and other hardly controllable answers that can compromise the efficacy of therapy [15]. The formulations tuned the release of the NPs, demonstrating the feasibility of our novel system as an edible nanocomposite
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