Abstract
To examine the association of colonization by Staphylococcus aureus and general population mortality, we followed 10,598 adults for 8.5 years on average. Methicillin-susceptible S. aureus colonization was not associated with death. Methicillin-resistant S. aureus carriage predicted death in a crude analysis but not after adjustment for socioeconomic status and co-morbidities.
Highlights
To examine the association of colonization by Staphylococcus aureus and general population mortality, we followed 10,598 adults for 8.5 years on average
Staphylococcus aureus is a common cause of mild to lifethreatening infections. It is differentiated into methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA); the emergence of isolates resistant to vancomycin has raised concern that the bacterium might become untreatable with current antimicrobial drugs [1]
In line with the inverse association in our unadjusted analysis for MSSA and mortality, Wertheim et al found that MSSA-colonized participants had longer survival than did noncolonized participants among patients with S. aureus bacteremia [3]
Summary
Colonization (HR 4.05, 95% CI 2.42–6.79) in univariate analyses but not after adjustment for sociodemographic characteristics. Colonization with SCCmec type IV MRSA was not associated with death in univariate or adjusted analysis, unlike no S. aureus or MSSA colonization (Table 2). The small number of participants with MRSA SCCmec types II [83] and IV [53] limited our analysis
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