Abstract
Staphylococcus aureus Bacteremia due to Central Venous Catheter Infection: A Clinical Comparison of Infections Caused by Methicillin-Resistant and Methicillin-Susceptible Strains
Highlights
Staphylococcus aureus (S.aureus) bacteremia has a mortality rate ranging from 20-40%
methicillin resistant S.aureus (MRSA) carriers and older patients were at a higher risk of MRSA Central venous catheter (CVC) infection compared to methicillin sensitive S.aureus (MSSA) bacteremia patients
We investigated the following clinical factors, comparing them between MRSA and MSSA bacteremia patients: baseline characteristics, age, sex, MRSA carrier, baseline diseases, ICU admission during hospitalization, surgery, total parenteral nutrition (TPN), steroid use, chemotherapy, immunosuppressant use, and complications such as endophthalmitis, infective endocarditis, deep abscess, septic shock, antimicrobial treatment, duration of CVC replacement, time lag from the day of symptom onset of the infection to the day of CVC removal, and time lag from symptom onset to the day of starting effective antimicrobial therapy (Cloxacillin or Cefazolin for MSSA,and Vancomycin(VCM) or Daptomycin for MRSA)
Summary
Staphylococcus aureus (S.aureus) bacteremia has a mortality rate ranging from 20-40%. Central venous catheter (CVC) infection is the leading cause of S.aureus bacteremia. We investigated the differences in background characteristics, complications, and prognosis between patients with methicillin resistant S.aureus (MRSA) and methicillin sensitive S.aureus (MSSA) bacteremia due to CVC infection. The risk factors for S.aureus bacteremia include central venous catheter (CVC), solid tumor, chronic kidney disease, history of hospitalization, and prolonged antimicrobial use. CVC infection caused by S.aureus is a major cause of S.aureus bacteremia and is an important healthcare associated infection [2,3]. There are few studies, that investigated the differences and prognosis comparing MRSA bacteremia patients with MSSA bacteremia patients, secondary to CVC infection. The purpose of this study was to investigate the differences of clinical backgrounds, complications and prognosis, comparing MRSA bacteremia patients with MSSA bacteremia patients, secondary to CVC infection at St. Luke's International Hospital
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