Abstract
Analyze nasal colonization by oxacillin-sensitive and oxacillin-resistant Staphylococcus aureus in people with HIV/AIDS (PWHA) at days 1 and7 of hospitalization. A prospective observational study conducted in a hospital in the countryside of the state of São Paulo. Nasal swab samples were collected and analyzed through microbiological identification, at days 1 and 7 of hospitalization of PWHA, between August 2011 and January 2014. Data were analyzed via IBM SPSS(r), version 20.0. Nasal secretion samples were collected from 187 (50.1%) PWHA at days 1 and 7 of hospitalization. Of these, Staphylococcus aureus was identified in 64 (34.2%) PWHA. At day 1 of hospitalization, 27 PWHA were identified with Staphylococcus aureus; 27 PWHA presented colonization by Staphylococcus aureus at days 1 and 7, and 10 PWHA only at day 7. Of 64 PWHA colonized by Staphylococcus aureus, the susceptibility profile of isolated Staphylococcus aureus was oxacillin-resistant in 25 PWHA. Analisar a colonização nasal por Staphylococcus aureus sensíveis e resistentes à oxacilina de pessoas vivendo com HIV/aids (PVHA) no primeiro e no sétimo dia de internação hospitalar. Estudo prospectivo observacional realizado em um hospital do interior paulista. Foram coletadas e analisadas, por meio de identificação microbiológica, amostras de swab nasal no primeiro e no sétimo dia de internação hospitalar de PVHA, no período de agosto/2011 e janeiro/2014. A análise dos dados foi realizada por meio do IBM SPSS(r), versão 20.0. Em 187 (50,1%) PVHA foram coletadas amostras de secreção nasal no primeiro e sétimo dia de internação. Destas, em 64 (34,2%) foi identificado Staphylococcus aureus. No primeiro dia de internação observou-se 27 PVHA colonizadas por Staphylococcus aureus; em 27 PVHA houve a persistência da colonização por Staphylococcus aureus no primeiro e no sétimo dia; em 10 PVHA, somente no sétimo dia. Das 64 PVHA colonizadas por Staphylococcus aureus, em 25 o perfil de suscetibilidade do Staphylococcus aureus isolado foi resistente à oxacilina.
Highlights
Human beings are natural reservoirs of Staphylococcus aureus, a bacterium that is especially found in the nose, vagina, pharynx and/or injured skin surfaces[1]
Infections caused by Staphylococcus aureus have been considered the major cause of morbimortality of people living with human immunodeficiency virus (HIV)/AIDS (PWHA), due to virulence factor of this microorganism and its resistance to antibiotics
A case-control study conducted in Singapore, which attempted to identify Methicillin-resistant Staphylococcus aureus (MRSA) in people with HIV/AIDS at hospital admission, showed the main site of colonization by this microorganism were the nares of participants[7]
Summary
Human beings are natural reservoirs of Staphylococcus aureus, a bacterium that is especially found in the nose, vagina, pharynx and/or injured skin surfaces[1]. Once natural protection barrier is past, the microorganism can access underlying layers of the skin and, in favorable conditions, it may cause an infection[2,3]. An infection situation can be very serious in immunocompromised patients, such as those with the human immunodeficiency virus (HIV ), serious burns and cancer, increasing the morbimortality rate, length of hospital stay and healthcare costs[4]. Infections caused by Staphylococcus aureus have been considered the major cause of morbimortality of people living with HIV/AIDS (PWHA), due to virulence factor of this microorganism and its resistance to antibiotics. Microbial resistance is one of the major concerns of public health, with serious economic, social and political implications that affect individuals globally, going beyond environmental and ethnical boundaries[5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
