Staphylococcus aureus and Staphylococcus epidermidis Strain Diversity Underlying Pediatric Atopic Dermatitis

Abstract

AL Byrd, Deming, SKB Cassidy; NISC Comparative Sequencing Program. Sci Transl Med. 2017;9(397):eaal4651 Atopic dermatitis (AD) is a complex and multifactorial disease. Authors of previous studies have used traditional typing methods on cultivated isolates or have sequenced a bacterial marker gene to study the skin microbial communities of patients with AD. A shotgun metagenomic sequencing analysis provides greater resolution, elucidating multiple levels of microbial community assembly. Eleven children with moderate to severe AD and 7 healthy children were recruited to the National …