Abstract
Stanniocalcin-2 (STC2) has been proved to regulate a variety of signaling pathways including cell growth, metastasis, and therapeutic resistance. However, the role of STC2 in the regulation of nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, we investigated the regulatory function of STC2 on epithelial-mesenchymal transition (EMT) and glycolysis traits in NPC and revealed the underlying molecular mechanisms. We found that STC2 was highly expressed in primary nasopharyngeal carcinoma tissues and lymph node metastatic tissues. Silencing of STC2 inhibited cell proliferation, invasion, and glycolysis. Further analyses for the clinical samples demonstrated that STC2 expression was associated with the poor clinical progression. Moreover, we demonstrated the interaction of ITGB2 with STC2 and its involvement in STC2-mediated ITGB2/FAK/SOX6 axis. Collectively, our results provide new insights into understanding the regulatory mechanism of STC2 and suggest that the STC2/ITGB2/FAK/SOX6 signaling axis may be a potential therapeutic target for NPC.
Highlights
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor associated with Epstein–Barr virus (EBV) infection (Strazzulla et al 2015; Raab-Traub 2002)
We found that poor overall survival (OS) and disease-free survival (DFS) were significantly associated with STC2 expression (Fig. 1d)
These results indicate that STC2 is upregulated in nasopharyngeal carcinoma and involved in tumorigenesis and metastasis
Summary
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor associated with Epstein–Barr virus (EBV) infection (Strazzulla et al 2015; Raab-Traub 2002). The overall survival of NPC patients has been significantly improved with the advancement of radiotherapy technology and chemotherapy, a large proportion of NPC patients still developed recurrence or distant metastasis due to the radioresistance or late recognition (Lee et al 2005). The failure of these treatments greatly threatens the patient’s long-term survival and the quality of life.
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