Abstract
Unstable liquid flow in syringe pump-driven systems due to the low-speed vibration of the step motor is commonly observed as an unfavorable phenomenon, especially when the flow rate is relatively small. Upon the design of a convenient and cost-efficient microfluidic standing air bubble system, this paper studies the physical principles behind the flow stabilization phenomenon of the bubble-based hydraulic capacitors. A bubble-based hydraulic capacitor consists of three parts: tunable microfluidic standing air bubbles in specially designed crevices on the fluidic channel wall, a proximal pneumatic channel, and porous barriers between them. Micro-bubbles formed in the crevices during liquid flow and the volume of the bubble can be actively controlled by the pneumatic pressure changing in the proximal channel. When there is a flowrate fluctuation from the upstream, the flexible air-liquid interface would deform under the pressure variation, which is analogous to the capacitive charging/discharging process. The theoretical model based on Euler law and the microfluidic equivalent circuit was developed to understand the multiphysical phenomenon. Experimental data characterize the liquid flow stabilization performance of the flow stabilizer with multiple key parameters, such as the number and the size of microbubbles. The developed bubble-based hydraulic capacitor could minimize the flow pulses from syringe pumping by 75.3%. Furthermore, a portable system is demonstrated and compared with a commercial pressure-driven flow system. This study can enhance the understanding of the bubble-based hydraulic capacitors that would be beneficial in microfluidic systems where the precise and stable liquid flow is required.
Highlights
Microfluidics is the science and technology of systems that process small amounts of fluids, using channels with dimensions of tens to hundreds of micrometers [1]
Common fluidic actuation methods can be categorized as passive methods and active methods
Passive methods, including a capillary pump [14,15], thermal actuation [16], gravitational pumping, and so on, are dependent on fewer accessories, which allows them to be integrated with various active methods
Summary
Microfluidics is the science and technology of systems that process small amounts of fluids, using channels with dimensions of tens to hundreds of micrometers [1]. Passive methods, including a capillary pump [14,15], thermal actuation [16], gMraivcriotmaaticohinneasl2p02u0m, 11p,i3n9g6 , and so on, are dependent on fewer accessories, which allows them to obfe integrated with various devices. PDMS (Polydimethylsiloxane) surfaces are sensitive to environmental conditions and handling protocols, becoming either hydrophilic or hydrophobic or varying between both states This does not affect the formation process of the microbubble once the crevice angles are designed far away from the swing range of the advancing contact angle. It can be found that both the volume variation rate and change illustrated a uniformity during each positive or negative pressure interval
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