Standardized Rhus verniciflua stokes extract and its major flavonoid fustin attenuate oxidative stress induced by tert-butyl hydroperoxide via activation of nuclear factor erythroid 2-related factor

Abstract

The antioxidant effects of an urushiol-free standardized Rhus verniciflua Stokes (RVS) extract and fustin were investigated using oxidative stress-induced rats by tert-butyl hydroperoxide (t-BHP). Hepatic glutathione levels were higher in RVS and fustin groups than those of the t-BHP treated control group. The level of hepatic nuclear factor erythroid 2-related factor was increased by RVS and fustin. The histology results indicated that rats fed RVS had a lower rate of necrosis than the control rats injected with t-BHP.