Abstract
Five anti-diabetic thiazolidinediones have been chromatographed on C 18 TLC plates with binary mobile phases containing water and the organic modifiers acetone, 1,4-dioxane, or methanol. Linear relationships were obtained between the R M values of the compounds and the concentration of organic modifier in the mobile phase. These R M values enabled calculation of R M0 values by extrapolation. Calibration equations were then obtained for nine standards of known lipophilicity in the range 0.83–6.04. From these equations the partition coefficients log P EXP were calculated for the drugs. Lipophilicity values were also calculated by use of computational methods. Finally, interesting relationships were obtained between experimental and theoretical log P values and pharmacological data from the literature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
