Abstract
Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation. Mice in the treatment group were orally administered PM014 six times for 2 weeks. Effects of PM014 on radiation pneumonitis were evaluated based on histological findings and differential cell count in bronchoalveolar lavage fluid. PM014 treatment significantly inhibited immune cell recruitment and collagen deposition in lung tissue. Normal lung volume, evaluated by radiological analysis, in PM014-treated mice was higher compared to that in irradiated control mice. PM014-treated mice exhibited significant changes in inspiratory capacity, compliance and tissue damping and elastance. Additionally, PM014 treatment resulted in the downregulation of inflammatory cytokines, chemokines, and fibrosis-related genes and a reduction in the transforming growth factor-β1-positive cell population in lung tissue. Thus, PM014 is a potent therapeutic agent for radiation-induced lung fibrosis and inflammation.
Highlights
Thoracic radiation therapy is commonly used for treatment of lung and breast cancers as well as various lymphomas[1,2,3]
We investigated whether oral administration of PM014 reduces radiation-induced pneumonitis and influences lung function in an ablative radiation-induced lung inflammation mouse model
We investigated whether PM014, a herbal mixture, has any influence on radiation-induced lung inflammation using an ablative radiation-induced acute lung injury mouse model
Summary
Thoracic radiation therapy is commonly used for treatment of lung and breast cancers as well as various lymphomas[1,2,3]. Transforming growth factor-β, the most extensively investigated radiation-induced cytokine, plays a key role in mediation of tissue response involved in the progress of pneumonitis[7,8]. This inflammatory cytokine could be an effective inhibitory target for the prevention of radiation pneumonitis. Stereotactic body radiotherapy (SBRT), a recently developed technique, delivers high doses of ablative radiation to tumours in a single fraction, with greater accuracy than conventional fractionated radiotherapy (CFRT) It has become the standard radiotherapy method for early-stage lung cancer[11,12]. We investigated whether oral administration of PM014 reduces radiation-induced pneumonitis and influences lung function in an ablative radiation-induced lung inflammation mouse model
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