Abstract
Cardimap tablet is a polyherbal formulation manufactured by Maharishi Ayurveda and used as an antihypertensive. The Ayurvedic formulation contains Rauwolfia serpentina, Nardostachys jatamansi, Convolvulus pluricaulis, Bacopa monnieri, Piper longum, and hence contains five markers, namely, reserpine, lupeol, scopoletine, bacoside A and piperine. This paper reports the standardization of Cardimap tablet according to World Health Organization (WHO) guideline and also by high-performance thin-layer chromatography method for the presence of the markers reserpine, lupeol, scopoletine, bacoside A and piperine. Both marketed and lab preparation complied all parameters according to WHO guideline and each marker compound showed a linear relationship in the concentration range 1‒2 µg per spot for reserpine, 2.5‒4.5 µg per spot for scopoletine, 10–50 µg per spot for piperine, 12–24 µg per spot for bacoside A and 1‒5 µg per spot lupeol. The proposed method was found to be precise, specific, and accurate, with a recovery of 98‒102%, and hence can be used for the routine analysis of this formulation.
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