Abstract
A prospective study was carried out to establish normative data for splenic dimensions in North Indian population and their correlation with physical standard on abdominal CT of 21 patients aged between 20 and 70 years having no splenic disorders. Splenic volume was measured by two methods—volume and surface rendering technique of Able 3D doctor software and prolate ellipsoid formula. Volumes measured by both the techniques were correlated with their physical standards. Mean splenic volume was 161.57 ± 90.2 cm3 and range 45.7–271.46 cm3. The volume of spleen had linear correlation with body height (r = 0.512, P < .05). Splenic volume (cm3) = 7 × height (cm) − 961 can be used to generate normal standard volume of spleen as a function of body height in North Indian population (with 95% confidence interval). This formula can be used to objectively measure the size of the spleen in adults who have clinically suspected splenomegaly.
Highlights
Evaluation of splenic size by palpation can be extremely inaccurate because spleen is never palpable till it is enlarged 2 to 3 times its own size [1]
Volume calculated by prolate ellipsoid formula was 259.22 ± 118.92 cm3, and this significantly correlated with true volume measured by volume and surface rendering techniques (r = 0.929, P < .001, Figure 4)
In our study we found that splenic volume moderately correlated with age (r = 0.4, P < .05) and body surface area (BSA) (r = 0.433, P < .05)
Summary
Evaluation of splenic size by palpation can be extremely inaccurate because spleen is never palpable till it is enlarged 2 to 3 times its own size [1]. Determination of spleen size is important in diagnosing small, normal or enlarged spleens. Is an important clinical sign for diagnosing varieties of diseases, for example, portal hypertension, glycogen storage disorder, hematological malignancy, and other disorders [2, 3]. Various clinical and radiological techniques (USG and nuclear medicine) have been used to estimate organ volumes. Technique for determining splenic volume by ultrasonography had been presented in various studies [4]. Volume determination by 2D USG can be inaccurate because of the variable, irregular contour of spleen and overlapping of splenic outline by bone, bowel gas, or left kidney [5]. New 3D reconstruction of CT images is more accurate than 2D ultrasonography [6,7,8]
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