Abstract
BackgroundTo evaluate the effect of clinicopathologic factors on the prognosis and fertility outcomes of BOT patients.MethodsWe performed a retrospective analysis of BOT patients who underwent surgical procedures in West China Second University Hospital from 2008 to 2015. The DFS outcomes, potential prognostic factors and fertility outcomes were evaluated.ResultsFour hundred forty-eight patients were included; 52 recurrences were observed. Ninety-two patients undergoing FSS achieved pregnancy. No significant differences in fertility outcomes were found between the staging and unstaged surgery groups. Staging surgery was not an independent prognostic factor for DFS. Laparoscopy resulted in better prognosis than laparotomy in patients with stage I tumours and a desire for fertility preservation.ConclusionPatients with BOT fail to benefit from surgical staging. Laparoscopy is recommended for patients with stage I disease who desire to preserve fertility. Physicians should pay more attention to risk of recurrence in patients who want to preserve fertility.
Highlights
To evaluate the effect of clinicopathologic factors on the prognosis and fertility outcomes of Borderline ovarian tumour (BOT) patients
Li et al BMC Cancer (2020) 20:769 of implants include the omentum and peritoneal surfaces, comprehensive surgical staging including resection of the primary borderline tumour, abdominal/pelvic cytologic washings, omentectomy, and peritoneal biopsies is recommended
The majority of the patients were in Federation of Gynecology and Obstetrics (FIGO) stage I (n = 347, 77.46%), with a few cases of stage II (n = 20, 4.46%), stage III (n = 74, 16.52%), and stage IV (n = 7, 1.56%)
Summary
To evaluate the effect of clinicopathologic factors on the prognosis and fertility outcomes of BOT patients. Borderline ovarian tumour (BOT) is a unique type of tumour with a better prognosis than malignant ovarian tumours. BOT usually occurs in women 10 years younger than those with epithelial ovarian cancer. The majority of the women with BOT are diagnosed in earlier. The clinical management of BOT has evolved since our understanding of its biological behaviour has increased over the latest two decades. The primary treatment for BOT is surgical removal of the tumour, while fertility-sparing surgery (FSS) is emphasized in women who desire to preserve their fertility. The role of comprehensive surgical staging in the treatment of BOT is still controversial. Due to that peritoneal implants are a significant prognostic index and the most common sites
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