Staged implant placement after defect regeneration using biphasic calcium phosphate materials with different surface topographies in a minipig model

I Mihatovic,J Becker,R Sader,M Dard,G John,K Obreja,F Schwarz

doi:10.1007/s00784-020-03206-7

Abstract

ObjectiveTo assess the influence of biphasic calcium phosphate materials with different surface topographies on bone formation and osseointegration of titanium implants in standardized alveolar ridge defects.Materials and methodsStandardized alveolar ridge defects (6 × 6 mm) were created in the mandible of 8 minipigs and filled with three biphasic calcium phosphate materials (BCP1–3, 90% tricalcium phosphate/10% hydroxyapatite) with different surface properties (micro- and macroporosities) as well as a bovine-derived natural bone mineral (NBM) as a control. At 12 weeks, implants were placed into the augmented defects. After further 8 weeks of healing, dissected blocks were processed for histological analysis (e.g., mineralized (MT), residual bone graft material (BS), bone-to-implant contact (BIC)).ResultsAll four biomaterials showed well-integrated graft particles and new bone formation within the defect area. MT values were comparable in all groups. BS values were highest in the NBM group (21.25 ± 13.52%) and markedly reduced in the different BCP groups, reaching statistical significance at BCP1-treated sites (9.2 ± 3.28%). All test and control groups investigated revealed comparable and statistically not significant different BIC values, ranging from 73.38 ± 20.5% (BCP2) to 84.11 ± 7.84% (BCP1), respectively.ConclusionAll bone graft materials facilitated new bone formation and osseointegration after 12 + 8 weeks of healing.

Highlights

Bone grafting has become an important field in implant dentistry for the treatment of alveolar ridge defects due to trauma, Ilja Mihatovic and Karina Obreja contributed to the present study and are considered joint first-authors.periodontal disease, or infection
No complications such as allergic reactions, swellings, abscesses, or infections could be observed throughout the whole study period
After 12 + 8 weeks of healing, all histological specimens showed a bony filling of the secluded wound area treated with BCP1–3 and natural bone mineral (NBM) (Fig. 4a)

Summary

Introduction

Bone grafting has become an important field in implant dentistry for the treatment of alveolar ridge defects due to trauma, Ilja Mihatovic and Karina Obreja contributed to the present study and are considered joint first-authors.periodontal disease, or infection. Bone grafting has become an important field in implant dentistry for the treatment of alveolar ridge defects due to trauma, Ilja Mihatovic and Karina Obreja contributed to the present study and are considered joint first-authors. Experimental data indicated that the application of either a particulate xenograft or BCP showed predictable bone formation at chronic alveolar ridge defects in the posterior mandible revealing a vertical and horizontal bone deficiency [5, 6].

Methods

Results

Conclusion