Stage-Specific Relationship between Plasma Total and Cerebellar Bilirubin Levels during Early Postnatal Period in Jaundiced Gunn Rats

Abstract

Abstract Relationships between plasma total or unbound bilirubin level and cerebellar bilirubin level were examined during the first 14 days after birth in homozygous Gunn rats with hyperbilirubinemia. Correlation coefficients between plasma total and cerebellar bilirubin levels were 0.63, 0.74, 0.48 and 0.60 at days 3, 7, 9 and 11, respectively, and were all significant, whereas the coefficient at day 14 (0.10) was not significant. The correlation coefficients between plasma unbound and cerebellar bilirubin levels were 0.40, 0.09, and 0.12 at days 7, 11 and 14, respectively, and were not significant. Thus, the cerebellar bilirubin level is suggested to depend on the plasma total bilirubin level from day 3 to 11.