Abstract
The testis is an immune privileged organ that provides a specific environment for germ cell development. Various factors responsible for inflammatory changes can lead to deterioration of the immune tolerant model found in the testis. As a result, the thickness of the proper membrane of seminiferous tubules changes and the process of spermatogenesis is disturbed.
Highlights
The testis is an immune privileged organ that provides a specific environment for germ cell development
In the comparative analysis of the preparations in groups 2, 3, and 4, the membrana propria (MP) thickening was pronounced, accompanied by deposition of extracellular matrix between the myofibroblast layers, which was well visualized by haematoxylin and eosin (H&E) and azan staining, as well as with immunoreactivity for α-SMA
In group 2, we found MP thickening accompanied by deposition of extracellular matrix between the myofibroblast layers, which was visualized by H&E and azan staining and immunoreactivity for α-SMA
Summary
The testis is an immune privileged organ that provides a specific environment for germ cell development. The thickness of the proper membrane of seminiferous tubules changes and the process of spermatogenesis is disturbed. Results: By using testicular biopsy to diagnose patients with infertility, a stage-specific pattern of the processes associated with thickened proper membrane of seminiferous tubules was established and a decreased or absent spermatogenic activity was observed. Conclusions: A significant increase in the proper membrane thickness of the seminiferous tubules in the testis was found in patients with infertility. This finding shows that the processes take place gradually over time, correlating with the degree of pathology, and that changes do not depend on the factors causing them. Myofibroblasts located in the testis are the main component of MP of the seminiferous tubules
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