Abstract
Filtered culture fluids of the Stachybotrys chartarum strain were exhaustively extracted with ethyl acetate. The iso lated red residue was subjected to column chro matography (silica gel) with gradient elution, resulting in 2 different fractions. Fraction 1-2 consisted of a crystalline material that showed the same parameters of 1H and 13C as the parameters of staxibotrilaktam and staxibotrilaktam А, a derivative of driman's sesquiterpenoid. The structure proposed for this compound was based on spectroscopic data and no indication of the configuration of stereogenic carbon atoms was obtained. The fungus was produced mainly stachybotrys fully characterized derived sesquiterpenoid of drimana.
Highlights
Filtered culture fluids of the Stachybotrys chartarum strain were exhaustively extracted with ethyl acetate
The nutrient medium plays an important role in the growth, development and synthesis of secondary metabolites of microorganisms; the growth of microbial cells at temperatures optimal for their development ensures the maximum formation of secondary metabolites in the environment
When the micelles of the cultured Stachybotrys chartarum strain were filtered from the culture broth, 58 g of micellar biomass and 15 L of the culture broth were obtained
Summary
Filtered culture fluids of the Stachybotrys chartarum strain were exhaustively extracted with ethyl acetate. The poisonous properties of mushrooms are retained even when bread is baked from them [6,7] In such a situation, it became necessary to get acquainted with the results of the study of toxin-producing fungi, to determine their origin, distribution in nature and, on this basis, to create a system for combating the diseases they cause. When the micelles of the cultured Stachybotrys chartarum strain were filtered from the culture broth, 58 g of micellar biomass and 15 L of the culture broth were obtained. Chromatographic column chloroform: methanol (20: 1) was washed with systemic eluent to obtain 7.71 mg of amorphous monoacetate staxybotrylactam A (II), C26H35NO5, Rf = 0.36 (YuQX, silufol, system chloroform: methanol (10: 1). Stachybotrylactam A, one of the important products of the laboratory fungus Stachybotrys chartarum grown under laboratory conditions, was isolated using column chromatography and modified to study its structure (Figure 1). The presence of a singlet signal specific to a single aromatic proton indicates the presence of a single aromatic proton
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