Abstract
Upon depolarization, voltage-gated calcium channels (VGCC) open but then undergo inactivation. Two processes govern VGCC inactivation: calcium-dependent inactivation (CDI) and voltage-dependent inactivation (VDI). Recently, the members of the STAC family of adaptor proteins have been shown to inhibit CDI of L-type calcium channels, by binding to the C-terminal domain. Here, we demonstrate that STAC proteins also inhibit the VDI of CaV1.2 and CaV1.3. Remarkably, using a STAC mutant, we could demonstrate that the inhibition of VDI relies on the same interaction, between STAC and the calcium channel, as CDI.
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