Stable Solid-State Microfabricated Potentiometric Sensor Based on Chitosan- Prussian Blue Nanocomposite Film for Amlodipine Selective Detection

Abstract

Solid state ion-selective electrodes have a grown importance in advanced detection techniques especially with exploiting different solid contact transducing substances. Nowadays, various approaches focus on producing simple, sensitive, durable and significantly stable electrodes. Lower cost of production could be achieved by employing simple, economical and efficient materials in their fabrication. Herein, a solid state microfabricated copper electrode was firstly designed from a reasonably priced and easily fabricated copper printed circuit boards followed by applying chitosan-Prussian blue nanocomposite layer. Finally, amlodipine sensing membrane was added resulting in construction of an amlodipine sensing microfabricated solid-state electrode. The designed electrode was characterized by being miniaturized, durable, portable, easily fabricated, affordable and highly stable over 60 d with a potential drift value of 600 μV h−1. The microfabricated electrode revealed promising results upon the direct analysis of amlodipine besylate and the responses showed a good linear Nernstian pattern in the dynamic range of 1.0 ×10−5.5 to 1.0 ×10−3 mol l−1 with a slope of 55.1 mV/decade. The detection limit was found to be 2.0 ×10−6 mol l−1. Selective determination of the drug was successfully achieved in presence of its degradation product without any sample preparation steps.