Abstract
All infectious disease agents have specific mechanisms to colonize , invade , and overcome the host. By use of gene cloning and genetic and biochemical techniques , it is possible to elucidate these mechanisms in biochemical terms as well as to understand the biology by which pathogens accomplish these feats . Once these mechanisms are understood, the information can be used to design novel strategies to immunize the host to prevent infection and disease by the pathogen. Since most pathogens colonize on and invade through a mucosal surface, it is appropriate to develop an immunization strategy that elicits a mucosal immune response as well as production of serum IgG and a cellular immune response.
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