Abstract
Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing. Recent Advances: BPC 157 has practical applicability (given alone, with the same dose range, and same equipotent routes of application, regardless the injury tested). Critical Issues: By simultaneously curing cutaneous and other tissue wounds (colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, and rectovaginal) in rats, the potency of BPC 157 is evident. Healing of the wounds is accomplished by resolution of vessel constriction, the primary platelet plug, the fibrin mesh which acts to stabilize the platelet plug, and resolution of the clot. Thereby, BPC 157 is effective in wound healing much like it is effective in counteracting bleeding disorders, produced by amputation, and/or anticoagulants application. Likewise, BPC 157 may prevent and/or attenuate or eliminate, thus, counteract both arterial and venous thrombosis. Then, confronted with obstructed vessels, there is circumvention of the occlusion, which may be the particular action of BPC 157 in ischemia/reperfusion. Future Directions: BPC 157 rapidly increases various genes expression in rat excision skin wound. This would define the healing in the other tissues, that is, gastrointestinal tract, tendon, ligament, muscle, bone, nerve, spinal cord, cornea (maintained transparency), and blood vessels, seen with BPC 157 therapy.
Highlights
Since the wound healing therapy with the standard angiogenic growth factors may be of essential importance, we presented an overview of the stable gastric pentadecapeptide BPC 157 and wound-healing issue
Stable gastric pentadecapeptide BPC 157 is effective in wound healing (Seiwerth et al, 1997; Mikus et al, 2001; Sikiric et al, 2003; Xue et al, 2004a; Bilic et al, 2005; Seveljevic-Jaran et al, 2006; Tkalcevic et al, 2007; Huang et al, 2015), much like it is effective in counteracting bleeding disorders (Stupnisek et al, 2012; Stupnisek et al, 2015; Vukojevic et al, 2018), produced by amputation, and/or anti-coagulants application, or major vessel occlusion, along with the evidence that pentadecapeptide BPC 157 may prevent and/or attenuate or eliminate, counteracting both arterial thrombosis (Hrelec et al, 2009; Gojkovic et al, 2020; Kolovrat et al, 2020) and venous thrombosis (Vukojevic et al, 2018; Gojkovic et al, 2020; Kolovrat et al, 2020)
In rats with occluded blood vessels, at 1 and 24 h, BPC 157 demonstrated a particular specificity within the pathways and vessels involved (Vukojevic et al, 2018)
Summary
This stable gastric pentadecapeptide BPC 157 review (Seiwerth et al, 2018; Sikiric et al, 2020a; Sikiric et al, 2020b) is focused on the particular skin wound therapy, incisional/excisional wound (Seiwerth et al, 1997), deep burns (Mikus et al, 2001), diabetic ulcer (Tkalecevic et al, 2007), alkali burns (Huang et al, 2015), and healing of various other tissue types (Staresinic et al, 2003; Staresinic et al, 2006; Sever et al, 2009; Masnec et al, 2015; Becejac et al, 2018). BPC 157 beneficial activities was already appraised in several reviews (Sikiric et al, 1993; Sikiric et al, 2006; Sikiric et al, 2010; Sikiric et al, 2011; Sikiric et al, 2012; Sikiric et al, 2013; Seiwerth et al, 2014; Sikiric et al, 2014; Sikiric et al, 2016; Sikiric et al, 2017; Kang et al, 2018; Seiwerth et al, 2018; Sikiric et al, 2018; Gwyer et al, 2019; Park et al, 2020; Sikiric et al, 2020a; Sikiric et al, 2020b). To approach particular skin wound therapy, we and others reviewed the significance of its beneficial effect on muscle, tendon, ligament, and bone injuries (Gwyer et al, 2019; Seiwerth et al, 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
