Abstract
Objectives: Surgical replacement of aortic segments with synthetic prosthesises often is the therapy of choice. Drawbacks of these prosthesises include absence of function of windkessel with subsequent refractory hypertonia, limited options for therapy of prosthesis infection and the inability of the graft to remodel or to grow. Decellularized allogeneic grafts, reseeded with the recipient's cells according to the principles of tissue engineering could overcome these limitations. However, the initial mechanical capacity of decellularized grafts is insufficient to withstand pressures up to 240 mmHG. There is a strong need to support the decellularized graft until mechanical durability is achieved by physiologic remodelling processes.
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