Stabilization of virus-like particles with poly(2-oxazoline)s.

Abstract

Since the introduction of virus like particles (VLPs), as nanoscale building blocks,[1] they have become a favored material to fill the gap between supramolecular chemistry and microfabricated systems for medicine, materials science, and biotechnology. One great advantage of VLPs is their precisely defined structures, forming capsules for the packaging of proteins, catalysts, small molecules and other entities,[2] as well as for the display of functional molecules on their outer surfaces.[3] The stabilities of chemically modified particles are often approximately the same as the underivatized scaffolds, but in some cases stability is decreased.[4]