Stabilization of sulconazole nitrate in a topical powder formulation

Abstract

A mixture of sulconazole nitrate and talc appeared to be unstable under accelerated temperature conditions. The rate of degradation was influenced by temperature and the source of talc. Acid washing of the talc or addition of acidic compounds seemed to accelerate the degradation of sulconazole nitrate. The formulation was stabilized by the addition of basic metal salts of some inorganic or organic acids, such as sodium bicarbonate and sodium acetate. The stability was also influenced by the surface area of both the stabilizing agent and sulconazole nitrate